• Begin by preheating your oven to 350°F.

For the Meatloaf:

• In a skillet, melt the butter or drippings over medium heat. Add the diced onion and bell pepper, increasing the heat to medium-high, and sauté until they become caramelized, approximately 10-12 minutes. Stir in the garlic for an additional minute, then set aside to cool.
• In a large mixing bowl, combine the ground beef and season with salt, pepper, Cajun seasoning, paprika, thyme, basil, and dry mustard. Follow with ketchup and Worcestershire sauce.
• Soften the bread slices in the milk, then remove excess milk and crumble the bread into the meat mixture. Reserve any leftover milk.
• Whisk the eggs together with the reserved milk, and add the sautéed vegetables into the meat mixture. Use a wooden spoon to mix everything gently, being careful not to overly compress the meat. If necessary, pour in some of the reserved milk to add moisture.
• Form the meat into a loaf and place it into a baking pan, lightly pressing it to maintain its shape.

For the Glaze:

• In a small bowl, mix the remaining ketchup, Worcestershire sauce, and brown sugar to create the glaze. Spread this mixture over the top of the meatloaf.
• Bake the meatloaf in the preheated oven for about 60 minutes, or until the internal temperature reaches 160°F. If using a standard baking pan, drain any excess fat as it cooks.