In a big bowl, mix the chicken with Cajun seasoning, chili powder, garlic powder, hot sauce, and red chile flakes until well-coated.
Heat a large cast iron skillet over high heat and cook the seasoned chicken for about 10-15 minutes, making sure it’s fully cooked and reads at least 165°F on an instant-read thermometer. Avoid crowding the skillet; cook in batches if needed. Once done, transfer the chicken to a plate.
Using the same skillet, sauté the onion, tomatoes, corn, and jalapeños, adding a bit more Cajun seasoning. Cook until the veggies soften. Add the chicken back into the skillet and stir everything together.
Sprinkle the cheese and salsa over the chicken-veggie mix. Broil until the cheese melts.
Serve with tortilla chips, a dollop of sour cream, and some fresh basil.