Mix the flour, paprika, garlic powder, salt, and pepper together in a shallow dish.
Heat enough oil in a frying pan to cover the bottom evenly.
Pat the tilapia fillets dry with a paper towel, then coat them thoroughly in the seasoned flour mixture.
Place the fish in the preheated pan, cooking each side until they turn a crispy golden brown. Repeat the process, adding a little more oil between each batch of fish. Enjoy!