In a bowl, combine ground beef with garlic powder, onion powder, salt, and pepper. Mix gently until just blended.

Shape the beef mixture into 12 patties, making them slightly larger than the buns.

Heat a grill or skillet over medium-high heat. Cook the patties for 3-4 minutes per side until they are browned and cooked through.

In the last minute of cooking, place a half slice of cheddar cheese on each patty, covering to melt the cheese.

While the patties are cooking, brush the slider buns with melted butter and toast them lightly on the grill or in the skillet.

To assemble, place a patty on each toasted bun, add desired toppings, and serve immediately.